Kir3.1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Kir3.1 Antibody [NBP3-14384] - Immunohistochemistry of formalin-fixed, paraffin-embedded human heart after heat-induced antigen retrieval.

• Reactivity: Hu, Mu, Rt, Po, Av, Bv, Ch, Eq, Gp, Ha, Pm, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Kir3.1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from internal region of human Kir3.1.
• Epitope: Internal
• Specificity: Human Kir3.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (100%), Rat (100%), Porcine (100%), Bovine (100%), Guinea Pig (100%), Avian (94%), Hamster (100%), Chicken (94%), Primate (100%), Equine (100%), Monkey (100%). Backed by our 100% Guarantee.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNJ3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: .

Reactivity Notes

Expected reactivity based on percent sequence identity: Bat (88%), Xenopus (81%)

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Kir3.1 Antibody - BSA Free

• G protein-activated inward rectifier potassium channel 1
• GIRK1
• GIRK-1
• GIRK1Kir3.1
• Inward rectifier K(+) channel Kir3.1
• inward rectifier K+ channel KIR3.1
• KCNJ3
• KGA
• Kir3.1
• Potassium channel, inwardly rectifying subfamily J member 3
• potassium inwardly-rectifying channel, subfamily J, member 3

Background

G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbgamma subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbgamma dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbgamma dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNJ3