Kir3.1 Products

Kir3.1 Overexpression Lysate
Kir3.1 Overexpression Lysate
Species: Hu
Applications: WB
Kir3.1 Recombinant Protein An ...
Kir3.1 Recombinant Protein Antigen
Species: Hu
Applications: AC


G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbgamma subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbgamma dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbgamma dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.


Entrez Human
Uniprot Human
Product By Gene ID 3760
Alternate Names
  • inward rectifier K+ channel KIR3.1
  • Potassium channel, inwardly rectifying subfamily J member 3
  • G protein-activated inward rectifier potassium channel 1
  • Inward rectifier K(+) channel Kir3.1
  • KIR3.1
  • KGA
  • GIRK1Kir3.1
  • GIRK-1
  • potassium inwardly-rectifying channel, subfamily J, member 3

PTMs for Kir3.1

Learn more about PTMs related to Kir3.1.


Bioinformatics Tool for Kir3.1

Discover related pathways, diseases and genes to Kir3.1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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