Kell Antibody (MM0435-12X3)

Product Discontinued

Kell Antibody (MM0435-12X3) Summary

• Immunogen: Human Blood Group Kell Antigen
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KEL
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000

Reactivity Notes

Human. Mouse reactivity reported in scientific literature (PMID: 28630094).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for Kell Antibody (MM0435-12X3)

• CD238 antigen
• CD238
• EC 3.4.24.-
• ECE3
• KEL
• kell blood group antigen
• kell blood group glycoprotein
• Kell blood group
• Kell blood group, metalloendopeptidase
• Kell blood group, metallo-endopeptidase
• Kell

Background

KELL, also known as Kell blood group glycoprotein, is a 732 amino acid protein that is 83 kDa; expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix; links via a single disulfide bond to the XK membrane protein that carries the Kx antigen; it is a zinc endopeptidase with endothelin-3-converting enzyme activity that cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. Disease research is currently being studied with relation to KELL and tinea corporis, fetal erythroblastosis, carbuncle, erysipelas, scabies, alloimmunization, tinea, chronic granulomatous disease, tonsillitis, pneumonia, tuberculosis, protein s deficiency, acute chest syndrome, and autoimmune hemolytic anemia. This protein involvement has been observed with relation to XK, EDN1, EDN2, EDN3, and EWSR1 in proteolysis and vasoconstriction pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kell Antibody (NBP2-11755)(2)

Publications using NBP2-11755

• Gibb DR, Liu J, Natarajan P et al. Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice. J. Immunol. 2017-06-19 [PMID: 28630094] (Mouse)
• Liu J, Santhanakrishnan M et al. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016-12-29 [PMID: 27688803] (WB, Human)

Bioinformatics

• Gene Symbol: KEL
• Uniprot:
  • P23276()