KChIP2 Antibody

Product Discontinued

KChIP2 Antibody Summary

• Immunogen: Synthetic Peptide: R(6) K E S L S D S R D L D G S Y D Q L T(24) C
• Localization: Cell Membrane; Lipid-anchor (By similarity).
• Specificity: Detects KChIP 2 b and c from rat and rabbit samples as well as recombinant rat KChIP 2c. This does not detect KChIP 2a.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNIP2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 2 ug/ml
• Application Notes: WB: Detects an approx. 33 and 26 kDa proteins representing KChIP2b and c, respectively, from rat ventricular myocyte whole cell lysate.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 17652182). Primate reactivity reported in scientific literature (PMID: 10676964).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for KChIP2 Antibody

• A-type potassium channel modulatory protein 2
• cardiac voltage gated potassium channel modulatory subunit
• Cardiac voltage-gated potassium channel modulatory subunit
• DKFZp566L1246
• KChIP2
• KCHIP2Kv channel-interacting protein 2
• Kv channel interacting protein 2
• MGC17241
• potassium channel interacting protein 2
• Potassium channel-interacting protein 2

Background

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function.There are currently three known KChIPs; KChIP 1 expressed in the brain; KChIP 2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP 3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNIP2
• Entrez:
  • 30819(Human)
  • 56817(Rat)