Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 426723
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Kallikrein 2
• Specificity: Detects human Kallikrein 2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Kallikrein 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or B1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 647]

• EC 3.4.21
• EC 3.4.21.35
• glandular kallikrein 2
• Glandular kallikrein-1
• hGK-1
• hK2
• Kallikrein 2
• kallikrein 2, prostatic
• kallikrein-2
• kallikrein-related peptidase 2
• Klk1c2
• KLK2
• KLK2A2
• MGC12201
• Tissue kallikrein-2
• Ton

Background

Kallikrein 2 (KLK2) is a secreted serine protease that is highly expressed in the human prostate gland (1). It is also known as the prostate-specific glandular kallikrein. The enzyme is highly specific for cleavage after arginine residues. KLK2 is able to activate the urokinase-type plasminogen activator (2). KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen activator inhibitor 1 (3‑5). KLK2 is structurally related to KLK3, the prostate-specific antigen (PSA). Like PSA, KLK2 is considered to be a biomarker for prostate cancer (6).

1. Chapelaine, P. et al. (1988) FEBS Lett. 236:205.
2. Frenette, G. et al. (1997) Int. J. Cancer 71:897.
3. Deperthes, D. et al. (1995) Biochim. Biophys. Acta 1245:311.
4. Grauer, L.S. et al. (1998) J. Androl. 19:407.
5. Mikolajczyk S.D. et al. (1999) Cancer Res. 59:3927.
6. Sardana, G. et al. (2008) Clin. Chem. 54:1951.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.