Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 426723
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Kallikrein 2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Kallikrein 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or B1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 2 Antibody (426723) [Alexa Fluor™ Plus 555]

• EC 3.4.21
• EC 3.4.21.35
• glandular kallikrein 2
• Glandular kallikrein-1
• hGK-1
• hK2
• Kallikrein 2
• kallikrein 2, prostatic
• kallikrein-2
• kallikrein-related peptidase 2
• Klk1c2
• KLK2
• KLK2A2
• MGC12201
• Tissue kallikrein-2
• Ton

Background

Kallikrein 2 (KLK2) is a secreted serine protease that is highly expressed in the human prostate gland (1). It is also known as the prostate-specific glandular kallikrein. The enzyme is highly specific for cleavage after arginine residues. KLK2 is able to activate the urokinase-type plasminogen activator (2). KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen activator inhibitor 1 (3‑5). KLK2 is structurally related to KLK3, the prostate-specific antigen (PSA). Like PSA, KLK2 is considered to be a biomarker for prostate cancer (6).

1. Chapelaine, P. et al. (1988) FEBS Lett. 236:205.
2. Frenette, G. et al. (1997) Int. J. Cancer 71:897.
3. Deperthes, D. et al. (1995) Biochim. Biophys. Acta 1245:311.
4. Grauer, L.S. et al. (1998) J. Androl. 19:407.
5. Mikolajczyk S.D. et al. (1999) Cancer Res. 59:3927.
6. Sardana, G. et al. (2008) Clin. Chem. 54:1951.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.