JNK1 Antibody

Product Discontinued

JNK1 Antibody Summary

• Immunogen: The antiserum was produced against synthesized peptide derived from human SAPK/JNK. The immunogen region is: Internal.
• Specificity: SAPK/JNK (Ab-185) Antibody detects endogenous levels of total SAPK/JNK protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAPK8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:4000
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Western Blot 1:500-1:1000

Reactivity Notes

Human,Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for JNK1 Antibody

• c-Jun N-terminal kinase 1
• EC 2.7.11
• EC 2.7.11.24
• JNK1 alpha protein kinase
• JNK1 beta protein kinase
• JNK1
• JNK1JNK1A2
• JNK-46
• JUN N-terminal kinase
• MAP kinase 8
• MAPK 8
• MAPK8
• mitogen-activated protein kinase 8 isoform JNK1 alpha1
• mitogen-activated protein kinase 8 isoform JNK1 beta2
• mitogen-activated protein kinase 8
• PRKM8
• PRKM8JNK
• protein kinase JNK1
• SAPK1
• SAPK1JNK21B1/2
• Stress-activated protein kinase 1
• Stress-activated protein kinase JNK1

Background

The MAPK family includes several subgroups encompassing the extracellular signal-regulated kinase (ERK) family, the p38 Map kinase family, and c-Jun NH2-terminal kinase (JNK) family. JNK kinase group includes 3 members, JNK1, JNK2, and JNK3. JNK kinases are phosphorylated in response to various activations by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulate AP-1 transcriptional activity. JNK kinases are characterized by requirement for dual phosphorylation at a T-P-Y motif for enzymatic activation. The Poly6331 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat JNK1 p46 and JNK3 p54 protein. c-Jun, Bcl2, MAP2K4, MAP2K7, ATF2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAPK8
• Uniprot:
  • P45983()