Jak3 Antibody (452524) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 452524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

Jak3 Antibody (452524) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Jak3 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Jak3 Antibody (452524) [Alexa Fluor™ Plus 555]

• EC 2.7.10
• Jak3
• JAK3_HUMAN
• JAK-3EC 2.7.10.2
• JAKL
• JAKLtyrosine-protein kinase JAK3
• Janus kinase 3Leukocyte janus kinase
• LJAK
• L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)

Background

Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.