Jak3 Products

Description

Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Bioinformatics

Entrez	16453 Mouse 25326 Rat 3718 Human
Uniprot	AAH28068 Human NM_000215 Human P52333 Human
Product By Gene ID	3718
Alternate Names	EC 2.7.10 JAK3_HUMAN JAK-3EC 2.7.10.2 JAKLtyrosine-protein kinase JAK3 Janus kinase 3Leukocyte janus kinase LJAK L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)

Research Areas for Jak3

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Protein Kinase
Signal Transduction
Tyrosine Kinases

Related Jak3 Blog Posts

Check out the latest blog posts on Jak3.

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.

Read more Jak3 related blogs.