Jak3 Products

Antibodies
Jak3 Antibody
Jak3 Antibody
NBP1-61704
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Jak3 Antibody (452524) [Uncon ...
Jak3 Antibody (452524) [Unconjugated]
MAB46991
Species: Hu
Applications: CyTOF-ready, ICC, ICFlow
Host: Mouse Monoclonal
Jak3 Antibody (452506)
Jak3 Antibody (452506)
MAB4699
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
Jak3 Overexpression Lysate (N ...
Jak3 Overexpression Lysate (Native)
NBL1-12094
Applications: WB
Proteins
Recombinant Human Jak3 Protei ...
Recombinant Human Jak3 Protein
H00003718-P01
Species: Hu
Applications: WB, ELISA, PA
Jak3 Recombinant Protein Anti ...
Jak3 Recombinant Protein Antigen
NBP2-49629PEP
Species: Hu
Applications: AC
RNAi
Jak3 RNAi
Jak3 RNAi
H00003718-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 3718
Alternate Names
  • LJAK
  • EC 2.7.10
  • JAK3_HUMAN
  • JAKLtyrosine-protein kinase JAK3
  • L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)
  • JAK-3EC 2.7.10.2
  • Janus kinase 3Leukocyte janus kinase

Research Areas for Jak3

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Protein Kinase
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for Jak3

Discover related pathways, diseases and genes to Jak3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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