Jak3 Products

Antibodies
Jak3 Antibody (5H2)
Jak3 Antibody (5H2)
NBP2-37737
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF
Host: Mouse Monoclonal
Jak3 Antibody (452506)
Jak3 Antibody (452506)
MAB4699
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Lysates
Jak3 Overexpression Lysate
Jak3 Overexpression Lysate
NBL1-12094
Species: Hu
Applications: WB
Proteins
Recombinant Human Jak3 GST (N ...
Recombinant Human Jak3 GST (N-Term...
H00003718-P01
Species: Hu
Applications: WB, ELISA, PA, AP
Jak3 Recombinant Protein Anti ...
Jak3 Recombinant Protein Antigen
NBP2-49629PEP
Species: Hu
Applications: AC

Description

Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 3718
Alternate Names
  • LJAK
  • EC 2.7.10
  • JAK3_HUMAN
  • JAKLtyrosine-protein kinase JAK3
  • L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)
  • JAK-3EC 2.7.10.2
  • Janus kinase 3Leukocyte janus kinase

Research Areas for Jak3

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Protein Kinase
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for Jak3

Discover related pathways, diseases and genes to Jak3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Jak3 Blog Posts

Check out the latest blog posts on Jak3.
Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.
Read more Jak3 related blogs.