IRS1 [p Ser616] Antibody (HIR-B1)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
HIR-B1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

IRS1 [p Ser616] Antibody (HIR-B1) Summary

Immunogen
Synthetic peptide phosphorylated at Ser 616 site
Modification
p Ser616
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IRS1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
Application Notes
The antibody can be used for indirect ELISA and WB.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IRS1 [p Ser616] Antibody (HIR-B1)

  • HIRS-1
  • insulin receptor substrate 1
  • IRS1
  • IRS-1

Background

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for IRS1 Antibody (NBP1-50756)

Discover related pathways, diseases and genes to IRS1 Antibody (NBP1-50756). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for IRS1 Antibody (NBP1-50756)

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Pathways for IRS1 Antibody (NBP1-50756)

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Research Areas for IRS1 Antibody (NBP1-50756)

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Blogs on IRS1.

Signalling Advances in Adiponectin Antibody Research
Adiponectin is an adipocytokine protein that positively regulates metabolism of lipids and glucose by suppressing glucose production from the liver, stimulating insulin sensitivity, and increasing the rate of fatty acid oxidation and glucose uptake. I...  Read full blog post.

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Bioinformatics

Gene Symbol IRS1
Entrez
Uniprot