IP3R3 Antibody

• Reactivity: Hu, Mu, Rt, Bv, Ca
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

IP3R3 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence C-DKKERPTDEEGFLH corresponding to internal region according to NP_002215.2.
• Specificity: No cross-reactivity expected with other types of ITPR
• Predicted Species: Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ITPR3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
• Application Notes: WB: Preliminary experiments gave an approx. 60 kDa band in human adipose, colon, duodenum, heart and liver lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 304 kDa band according to NP_002215.1. The 60 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for IP3R3 Antibody

• FLJ36205
• inositol 14,5-triphosphate receptor, type 3
• inositol 14,5-trisphosphate receptor type 3
• InsP3R3
• IP3 receptor isoform 3
• IP3 receptor
• IP3R 3
• IP3R
• IP3R3
• ITPR3
• Type 3 inositol 14,5-trisphosphate receptor
• Type 3 InsP3 receptor

Background

IP3R3 (inositol 1,4,5-triphosphate receptor type 3) is an intracellular calcium release channel that mediates calcium release from the endoplasmic reticulum. There are 3 mammalian IP3R receptors: IP3R1, IP3R2, and IP3R3. IP3R3 has been shown to play a role in olfactory mucus secretion and in the taste perception of sweet, savory (umami), and bitter substances.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IP3R3 Antibody (NB100-2545)(1)

Publication using NB100-2545

• Futatsugi A, Nakamura T, Yamada MK et al. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 2005-09-30 [PMID: 16195467]

Bioinformatics

• Gene Symbol: ITPR3
• Entrez:
  • 3710(Human)
• Uniprot:
  • NP_002215.1(Human)