Intelectin-2 Antibody (874029) [Alexa Fluor® 488]

• Applications: WB, IHC
• Clone: 874029
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Intelectin-2 Antibody (874029) [Alexa Fluor® 488] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Intelectin-2
  Met1-Tyr324
  Accession # Q8WWU7
• Specificity: Detects human Intelectin-2 in ELISA. In Direct ELISA, no cross-reactivity with recombinant human (rh) Intelectin-1, recombinant mouse (rm) Intelectin-1, or rmIntelectin-2 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Intelectin-2 (ITLN-2; also endothelial lectin 2 and HL-2) is a 37-41 kDa, likely Ca-dependent carbohydrate-binding lectin that is a member of the X-lectin family of molecules.  It is secreted by intestinal Paneth cells, and appears to participate in fungal microbe recognition.  The human ITLN-2 precursor is 325 amino acids (aa) in length (SwissProt #:Q8WWU7).  It contains a 26 aa signal sequence and a 299 aa mature region.  Although mouse ITLN-2 is reportedly GPI-linked, and mouse and human ITLN-2 show considerable C-terminal aa identity, it is not known if human ITNL-2 is also GPI-linked.  There is one fibrinogen-related domain in the mature molecule (aa 44-267).  One potential splice variant is reported that shows a premature truncation after Gly264.  Over aa 29-324, human ITLN-2 shares 79% aa sequence identity with mouse ITLN-2/ITLN-1b, and 85% aa sequence identity with human ITLN-1.      

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.