Integrin beta 6 Antibody (437211) [Allophycocyanin]

HT-29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human Integrin beta 6 APC-conjugated Monoclonal Antibody (Catalog # FAB4155A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Applications: Flow
• Clone: 437211
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Integrin beta 6 Antibody (437211) [Allophycocyanin] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha V beta 6
  Phe31-Val992 (Integrin alpha V) and Gly22-Asn707 (Integrin beta 6)
  Accession # P18564 (Integrin beta 6)
• Specificity: Detects human Integrin beta 6 in direct ELISAs.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGB6
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 6 Antibody (437211) [Allophycocyanin]

• Integrin beta 6
• integrin beta-6
• integrin, beta 6
• ITGB6

Background

Integrin beta 6 (ITG beta 6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha V and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta 6 is a type I transmembrane glycoprotein that is 767 amino acids (aa) in length. It contains a 688 aa extracellular domain (ECD) (aa 22-709) that incorporates a 241 aa VWF-A domain. Over aa 22-707, human integrin beta 6 ECD shares 90% and 93% aa sequence identity with mouse and pig integrin beta 6 ECD, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin beta 6 Antibody (FAB4155A)(5)

Publications using FAB4155A

• MacDonald, WJ;Srinivasan, PR;Pinho-Schwermann, M;Zhang, S;Tajiknia, V;Purcell, C;Strandberg, J;Lannigan, AJ;El-Deiry, WS; Inhibition of ITGB6 stimulates potent anti-tumor responses in immunocompetent mouse models of head and neck squamous cell carcinoma and pancreatic adenocarcinoma American journal of cancer research 2025-12-25 [PMID: 41523261] (Flow Cytometry, Human)
• Okuwa, T;Himeda, T;Kobayashi, K;Nomura, N;Utani, K;Koike, S;Nakamura, A;Higuchi, M; Saffold virus exploits integrin ?v?8 and sulfated glycosaminoglycans as cooperative attachment receptors for infection Nature communications 2025-12-15 [PMID: 41397982] (Flow Cytometry, Human)
• Davies, DM;Pugliese, G;Parente Pereira, AC;Whilding, LM;Larcombe-Young, D;Maher, J; Engineering a Dual Specificity ?? T-Cell Receptor for Cancer Immunotherapy Biology 2024-03-20 [PMID: 38534465] (Flow Cytometry, Human)
• Stefano Tomassi, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Andrea Vannini, Giacomo Quilici, Michael Weinmüller et al. Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual alpha v beta 6/ alpha v beta 8 Integrin Ligand Journal of Medicinal Chemistry 2021-05-27 [PMID: 33961417]
• Anne C. Conibear, Sonja Hager, Josef Mayr, Matthias H. M. Klose, Bernhard K. Keppler, Christian R. Kowol et al. Multifunctional alpha v beta 6 Integrin-Specific Peptide–Pt(IV) Conjugates for Cancer Cell Targeting Bioconjugate Chemistry 2017-09-20 [PMID: 28796473]

Bioinformatics

• Gene Symbol: ITGB6
• Uniprot:
  • P18564 (Integrin beta 6)()