Importin alpha 5/KPNA1/SRP1 Antibody

Western Blot: Importin alpha 5/KPNA1/SRP1 Antibody [H00003836-A02] - Analysis of KPNA1 expression in PC-12.

Western Blot: Importin alpha 5/KPNA1/SRP1 Antibody [H00003836-A02] - Analysis of KPNA1 expression in NIH/3T3 (Cat # L018V1).

Western Blot: Importin alpha 5/KPNA1/SRP1 Antibody [H00003836-A02] - Analysis of KPNA1 expression in Raw 264.7.

Product Discontinued

Importin alpha 5/KPNA1/SRP1 Antibody Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: KPNA1 (AAH02374.1, 1 a.a. - 538 a.a.) full-length recombinant protein with GST tag. MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL
• Specificity: KPNA1 - karyopherin alpha 1 (importin alpha 5)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: KPNA1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Importin alpha 5/KPNA1/SRP1 Antibody

• Importin alpha 5
• importin subunit alpha-1
• importin-alpha-S1
• IPOA5
• karyopherin alpha 1 (importin alpha 5)
• Karyopherin subunit alpha-1
• KPNA1
• NPI-1
• NPI-1SRP1importin alpha 5
• Nucleoprotein interactor 1
• RCH2
• RCH2RAG cohort protein 2
• recombination activating gene cohort 2
• SRP1
• SRP1-beta

Background

Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Importin alpha 5/KPNA1/SRP1 Antibody (H00003836-A02)(1)

Publication using H00003836-A02

• Mahalakshmi RN, Ng MY, Guo K et al. Nuclear localization of endogenous RGK proteins modulation of cell shape remodeling by regulated nuclear transport. Traffic;8(9):1164-78. 2007-09-01 [PMID: 17605760]

Bioinformatics

• Gene Symbol: KPNA1
• Entrez:
  • 3836(Human)
• OMIM:
  • 600686(Human)
• Uniprot:
  • AAH02374(Human)