IL-22R alpha 1 Antibody (496514) [Unconjugated]


IL‑22 R alpha 1 was detected in immersion fixed Hepa 1‑6 mouse hepatoma cell line using Rat Anti-Mouse IL‑22 R alpha 1 Monoclonal Antibody (Catalog # MAB42941) at 10 µg/mL for 3 hours at room temperature. Cells more
Hepa 1‑6 mouse hepatoma cell line was stained with Rat Anti-Mouse IL‑22 R alpha 1 Monoclonal Antibody (Catalog # MAB42941, filled histogram) or isotype control antibody (Catalog # more
C2C12 cells were stained with Rat Anti-Mouse IL‑22 R alpha 1 Monoclonal Antibody (Catalog # MAB42941, filled histogram) or isotype control antibody (Catalog # MAB006, open histogram), followed by more

Product Details

Reactivity MuSpecies Glossary
Applications Flow, CyTOF-ready

Order Details

IL-22R alpha 1 Antibody (496514) [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse IL-22 R alpha 1
Accession # Q80XZ4
Detects mouse IL-22 R alpha 1 in direct ELISAs. In direct ELISAs, 25% cross-reactivity with recombinant human (rh) IL‑22 R alpha 1 is observed and no cross-reactivity with rhIL-20 R alpha , recombinant mouse (rm) IL-20 R alpha , rhIL-22BP, or rmIL-22BP is observed.
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
Read Publications using
MAB42941 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-22R alpha 1 Antibody (496514) [Unconjugated]

  • CRF2-9
  • CRF2-9interleukin 22 receptor
  • Cytokine receptor class-II member 9
  • Cytokine receptor family 2 member 9
  • IL-22 R alpha 1
  • IL-22 receptor subunit alpha-1
  • IL22R alpha 1
  • IL22R
  • IL22R1
  • IL22RA1
  • IL-22Ra1
  • IL-22R-alpha-1
  • IL-TIF-R1
  • interleukin 22 receptor, alpha 1
  • interleukin-22 receptor subunit alpha-1
  • zcytoR11


The IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa type I transmembrane glycoprotein that belongs to the type II cytokine receptor family (CRF). IL-22 R alpha 1 contains a 211 amino acid (aa) extracellular domain (ECD) with two fibronectin type III repeats, and a 330 aa cytoplasmic domain (1). Within the ECD, mouse IL-22 R alpha 1 shares 78%, 78%, and 94% aa sequence identity with canine, human, and rat IL-22 R alpha 1, respectively. It shares 20%‑26% aa sequence identity with the ECDs of other class II receptors IL-10 R, IL-20 R, and IL-28 R. IL-22 R alpha 1 associates with either IL-10 R beta or IL-20 R beta to form receptor complexes with distinct ligand selectivities. IL-10 R beta is a shared subunit of the IL-10, -22, -26, -28, and -29 receptors, while IL-20 R beta is a shared subunit of the IL-19, -20, -22, and -24 receptors (2). IL-22 R alpha 1/IL-10 R beta is an IL-22 responsive receptor (3, 4), and IL-22 R alpha 1/IL-20 R beta is an IL-20 or IL-24 responsive receptor (5, 6). In both cases, IL‑22 R alpha 1 functions as the high affinity ligand binding subunit, and subsequent association with IL-10 R beta or IL-20 R beta serves to stabilize the complex (3, 6‑9). IL‑22 R alpha 1 contains cytoplasmic motifs for interactions with signal transduction molecules, but association with IL-10 R beta or IL-20 R beta is required for signal transduction (3, 7). IL-22BP functions as a competitive antagonist by binding IL-22 and preventing its association with IL-22 R alpha 1 (8, 10). Even though it is a receptor for interleukins, IL‑22 R alpha 1 is not expressed on hematopoietic cells (7, 11, 12). Instead, IL-22 R alpha 1 expression is restricted to epithelial and stromal cells (7, 11‑14). IL‑22 R alpha 1 signaling promotes innate immune responses and wound healing at sites of infection and inflammation. This includes upregulation of antimicrobial, acute phase, proinflammatory, and extracellular matrix proteins as well as proteases (4, 12, 14, 15). IL‑22 R alpha 1 signaling also promotes downregulation of proteins involved in keratinocyte differentiation (4, 15).

  1. Tachiiri, A. et al. (2003) Genes Immun. 4:153.
  2. Langer, J.A. et al. (2004) Cytokine Growth Factor Rev. 15:33. 
  3. Xie, M-H. et al. (2000) J. Biol. Chem. 275:31335. 
  4. Boniface, K. et al. (2005) J. Immunol. 174:3695. 
  5. Dumoutier, L. et al. (2001) J. Immunol. 167:3545. 
  6. Wang, M. et al. (2002) J. Biol. Chem. 277:7341. 
  7. Kotenko, S.V. et al. (2001) J. Biol. Chem. 276:2725. 
  8. Li, J. et al. (2004) Int. Immunopharmacol. 4:693.
  9. Logsdon, N.J. et al. (2002) J. Interferon Cytokine Res. 22:1099
  10. Kotenko, S.V. et al. (2001) J. Immunol. 166:7096.
  11. Nagalakshmi, M.L. et al. (2004) Int. Immunopharmacol. 4:577.
  12. Nagalakshmi, M.L. et al. (2004) Int. Immunopharmacol. 4:679.
  13. Aggarwal, S. et al. (2001) J. Interferon Cytokine Res. 21:1047.
  14. Wolk, K. et al. (2004) Immunity 21:241.
  15. Wolk, K. et al. (2006) Eur. J. Immunol. 36:1309.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-22R alpha 1 Antibody (MAB42941)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Flow Cytometry, ICC, IHC, IHC-Fr.

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Showing Publications 1 - 9 of 9.
Publications using MAB42941 Applications Species
SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models Nat Commun, 2020;11(1):4611. 2020 [PMID: 32929072] (IHC, Human) IHC Human
F Madouri, O Barada, G Kervoaze, F Trottein, M Pichavant, P Gosset Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae EBioMedicine, 2018;0(0):. 2018 [PMID: 30361066] (IHC, Mouse) IHC Mouse
YH Hsu, HH Li, JM Sung, WY Chen, YC Hou, YH Weng, WT Lai, CH Wu, MS Chang Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy Exp. Mol. Med., 2017;49(3):e310. 2017 [PMID: 28360429] (ICC, Mouse) ICC Mouse
P Treerat, O Prince, A Cruz-Lagun, M Muñoz-Torr, MA Salazar-Le, M Selman, B Fallert-Ju, TA Reinhardt, JF Alcorn, D Kaushal, J Zuñiga, J Rangel-Mor, JK Kolls, SA Khader Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection Mucosal Immunol, 2017;0(0):. 2017 [PMID: 28247861] (IHC, Mouse) IHC Mouse
A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice Nat Commun, 2016;7(0):13896. 2016 [PMID: 27982034] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Justa S, Zhou X, Sarkar S Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-gamma responses. PLoS ONE, 2014;9(3):e93279. 2014 [PMID: 24676270] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Kumar P, Thakar M, Ouyang W, Malarkannan S IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol, 2013;6(1):69-82. 2013 [PMID: 22739232] (IHC-Fr, Mouse) IHC-Fr Mouse
Li Z, Burns AR, Miller SB, Smith CW CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing. FASEB J., 2011;25(8):2659-68. 2011 [PMID: 21518851] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Lindroos J, Svensson L, Norsgaard H IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6. J. Invest. Dermatol., 2011;131(5):1110-8. 2011 [PMID: 21289639] (IHC, Mouse) IHC Mouse

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Gene Symbol IL22RA1