IL‑20 R alpha was detected in immersion fixed paraffin-embedded sections of human skin using 8 µg/mL Mouse Anti‑HumanIL‑20 R alpha Monoclonal Antibody (Catalog # MAB11761) overnight at 4 °C. Tissue was stained ...read more
Mouse myeloma cell line NS0-derived recombinant human IL-20 R alpha Val30-Lys250 Accession # Q9UHF4
Detects human IL-20 R alpha in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse (rm) IL-20 R alpha is observed and no cross-reactivity with rmIFN-alpha / beta R2, recombinant human (rh) IFN-gamma R1, rhIFN-gamma R2, rhIL-10 R beta , or rhIL‑20 R beta is observed.
Protein A or G purified from hybridoma culture supernatant
Test in a species/application not listed above to receive a full credit towards a future purchase.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IL-20R alpha Antibody (173707) [Unconjugated]
class II cytokine receptor ZCYTOR7
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
IL-20 R alpha
IL-20R1IL-20 receptor subunit alpha
interleukin 20 receptor, alpha
interleukin-20 receptor I
interleukin-20 receptor subunit alpha
IL-20 receptor alpha (IL-20 R alpha ), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid (aa) residues in their extracellular domains, which are composed of tandem fibronectin type III domains (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1).
The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain (2). IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland (1). The expression of IL-20 R alpha , together with that of IL-20 R beta , is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells (1, 2).
IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals (3, 4). IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26 (5). Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes (3‑5).
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
Review this Product
Be the first to review our IL-20R alpha Antibody (173707) [Unconjugated] and receive a gift card or discount.