IL-1Rrp2/IL-1R6 Antibody [Biotin]

Images

 
There are currently no images for IL-1Rrp2/IL-1R6 Antibody (BAF872).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations

IL-1Rrp2/IL-1R6 Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL‑1 Rrp2/IL‑1 R6
Asp20-Tyr337
Accession # Q9HB29
Specificity
Detects human IL‑1 Rrp2/IL‑1 R6 in Western blots. In Western blots, less than 5% cross‑reactivity with recombinant rat IL-1 R6 is observed and less than 1% cross-reactivity with recombinant human (rh) IL-1 RI and rhIL-1 RII is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IL1RL2
Purity
Antigen Affinity-purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Purity
Antigen Affinity-purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL‑1 R4), IL‑18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain (1). Human IL-1 Rrp2 cDNA encodes a 561 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 318 aa extracellular domain. It shares 67% and 65% amino acid sequence identity with rat and mouse IL 1 Rrp2, respectively. IL-1 Rrp2 is expressed in lung epitheium, brain vasculature, kidney, testis, onocytes, skin-derived keratinocytes, fibroblasts and, to a lesser extent, endothelial cells (2, 3). IL-1 Rrp2 has been shown to mediate the activation of the transcription factor NF kappa B by the IL-1 family ligands IL-1 F6, F8 or F9 (also known as IL-1 epsilon ), with IL-1RAcP as a co‑factor (3, 4). Response to IL-1 F9 is specifically antagonized by IL‑1 F5 (also known as IL-1δ), an IL-1 family ligand that is most closely related to IL-1ra (3). IL-1 Rrp2, IL‑1 F5, and IL-1 F9 are all up-regulated in lesional psoriasis skin, suggesting that the IL-1 Rrp2 mediated signaling pathway may take part in local inflammatory responses (3).

 

  1. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
  2. Lovenberg, T. W. et al. (1996) J. Neuroimmunol. 70:113.
  3. Debets, R. et al. (2001) J. Immunol. 167:1440.
  4. Towne, J. E. et al. (2004) J. Biol. Chem. 279:13677.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

201-LB/CF
Species: Hu
Applications: BA
6835-IL/CF
Species: Hu
Applications: BA
MAB840
Species: Hu
Applications: CyTOF-ready, Flow, ICC, IHC, Neut
DST200
Species: Hu
Applications: ELISA
AF676
Species: Hu
Applications: CyTOF-ready, Flow, WB
DRA00B
Species: Hu
Applications: ELISA
D6050
Species: Hu
Applications: ELISA
AF1099
Species: Hu
Applications: Block, Neut, WB
7625
Species: Mu
Applications: ELISA
NBP2-76871
Species: Hu, Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-P, WB
1275-IL/CF
Species: Hu
Applications: BA
NB100-56583
Species: Hu, Rb, Rt
Applications: Flow, IHC, IHC-P, KO, WB
AF771
Species: Mu
Applications: IHC, Neut, WB
MAB17761
Species: Hu, Mu, Rt
Applications: ICC, WB
NBP2-22203
Species: Hu, Pm, Mu, Rt
Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB

Publications for IL-1Rrp2/IL-1R6 Antibody (BAF872) (0)

There are no publications for IL-1Rrp2/IL-1R6 Antibody (BAF872).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for IL-1Rrp2/IL-1R6 Antibody (BAF872) (0)

There are no reviews for IL-1Rrp2/IL-1R6 Antibody (BAF872). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for IL-1Rrp2/IL-1R6 Antibody (BAF872) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional IL-1Rrp2/IL-1R6 Products

Bioinformatics Tool for IL-1Rrp2/IL-1R6 Antibody (BAF872)

Discover related pathways, diseases and genes to IL-1Rrp2/IL-1R6 Antibody (BAF872). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-1Rrp2/IL-1R6 Antibody (BAF872)

Discover more about diseases related to IL-1Rrp2/IL-1R6 Antibody (BAF872).
 

Pathways for IL-1Rrp2/IL-1R6 Antibody (BAF872)

View related products by pathway.

Blogs on IL-1Rrp2/IL-1R6

There are no specific blogs for IL-1Rrp2/IL-1R6, but you can read our latest blog posts.
Omicron Variant Antibodies

Contact Information

Download our Western Blot eHandbook

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our IL-1Rrp2/IL-1R6 Antibody [Biotin] and receive a gift card or discount.

Bioinformatics

Gene Symbol IL1RL2