IGFLR1/TMEM149 Antibody (905338) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 905338
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

IGFLR1/TMEM149 Antibody (905338) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human IGFLR1in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IGFLR1/TMEM149 Antibody (905338) [Alexa Fluor™ Plus 647]

• FLJ22573
• IGFLR1
• TMEM149
• transmembrane protein 149
• U2 small nuclear RNA auxiliary factor 1-like 4
• U2(RNU2) small nuclear RNA auxiliary factor 1-like 4
• U2AF1L4

Background

Insulin Growth Factor-like Family Receptor 1 (IGFLR1) is a 355 amino acid (aa) type 1a transmembrane protein that was identified in a screen for binding partners of human IGFL-1 (1). Mature human IGFLR1 consists of an extracellular domain (ECD) with two putative cysteine-rich domains (CRDs), a transmembrane region, and a cytoplasmic domain (1). Its structure has similarities to TNF receptor family members (1). Over the first 163 aa, human IGFLR1 shares 61% and 59% aa sequence identity with mouse and rat IGFLR1, respectively. In mice, IGFLR1 is expressed primarily on T cells and, similar to the human proteins, mouse IGFLR1 binds the mouse IGFL protein (1). Human IGFL-1 expression is enhanced by TNF-alpha treatment and was shown to be up-regulated in human psoriatic skin samples, suggesting that IGFLR1 may have a role during skin inflammation (1).

1. Lobito, A.A. et al. (2011) J. Biol. Chem. 286:18969.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.