IFN-alpha/beta R2 Antibody (237526)

• Reactivity: Mu
• Applications: WB
• Clone: 237526
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

IFN-alpha/beta R2 Antibody (237526) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse IFN-alpha / beta R2
  Met1-Ala239 (Lys160Asn)
  Accession # Q9D1R7
• Specificity: Detects mouse IFN-alpha / beta R2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) IFN-alpha / beta R1, recombinant mouse (rm) IFN-gamma R1, rmIFN-gamma R2, rhIL-10 R beta , rhIL-20 R beta , or rmIL‑20 R beta .
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: IFNAR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha/beta R2 Antibody (237526)

• beta receptor10
• human interferon alpha
• human interferon alpha/beta receptor
• IFNABR
• IFN-alpha binding protein
• IFN-alpha/beta R2
• IFN-alpha/beta receptor 2
• IFN-alpha-REC
• IFNAR2
• IFN-aR2
• IFNARB
• IFNbR2
• IFN-bR2
• IFN-R
• IFN-R-2
• interferon (alpha, beta and omega) receptor 2
• Interferon alpha binding protein
• interferon alpha/beta receptor 2
• interferon-alpha/beta receptor beta chain
• Type I interferon receptor 2

Background

IFN-alpha / beta R2 belongs to the type II cytokine receptor family. It associates with IFN-alpha / beta R1 to form the signaling receptor complex for the alpha and beta IFN subtypes. By alternative splicing, IFN-alpha / beta R2 can exist as a secreted soluble protein or as a type I membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-alpha/beta R2 Antibody (MAB1083)(1)

Publication using MAB1083

• Srivastava , Shivani, Koch , Meghan A, Pepper , Marion, Campbell , Daniel J Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med, 2014-04-07;211(5):961-74. 2014-04-07 [PMID: 24711580] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: IFNAR2
• Uniprot:
  • Q9D1R7()