IFN-alpha/beta R2 Antibody (122) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: Flow
• Clone: 122
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: CoraFluor 1

IFN-alpha/beta R2 Antibody (122) [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human IFN-alpha/beta R2 (Accession#: NP_997468.1; Met1-Lys243).
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: IFNAR2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for IFN-alpha/beta R2 Antibody (122) [CoraFluor™ 1]

• beta receptor10
• human interferon alpha
• human interferon alpha/beta receptor
• IFNABR
• IFN-alpha binding protein
• IFN-alpha/beta R2
• IFN-alpha/beta receptor 2
• IFN-alpha-REC
• IFNAR2
• IFN-aR2
• IFNARB
• IFNbR2
• IFN-bR2
• IFN-R
• IFN-R-2
• interferon (alpha, beta and omega) receptor 2
• Interferon alpha binding protein
• interferon alpha/beta receptor 2
• interferon-alpha/beta receptor beta chain
• Type I interferon receptor 2

Background

IFNAR2, also known as Interferon alpha/beta receptor 2, has 3 isoforms, an isoform 1 that is 515 amino acid and 58 kDa, an isoform 2 that is 331 amino acid and 37 kDa, and an isoform3 that is 239 amino acid and 27 kDa; expressed in blood cells, lymphoblastoid and fibrosarcoma cell lines, isoform 3 is detected in the urine; is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta, stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Current research is being performed on several diseases and disorders including interferon, hepatitis c, hepatitis b, multiple sclerosis, measles, hepatocellular carcinoma, liver disease, breast cancer, myeloma, carcinoma, melanoma, adenocarcinoma, respiratory syncytial virus bronchiolitis, portal vein thrombosis, dengue hemorrhagic fever, cervical intraepithelial neoplasia, renal cell carcinoma, hemorrhagic fever, hepatitis c, and japanese encephalitis. This protein has been shown to interact with over 50 proteins including USP18, STAT2, GNB2L1, JAK1, and IFNA13 in cytokine-cytokine receptor interaction, osteoclast differentiation, toll-like receptor signaling pathway, Jak-STAT signaling pathway, natural killer cell mediated cytotoxicity, hepatitis C, measles, THC differentiation pathway, regulation of IFNA signaling and influenza A pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IFNAR2