Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Immunogen affinity purified
Manufactured by SDIX's proprietary Genomic Antibody Technology. GAT FAQs.
Alternate Names for IFN-alpha/beta R1 Antibody
alpha-type antiviral protein
beta-type antiviral protein
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
IFN-alpha/beta receptor 1
interferon (alpha, beta and omega) receptor 1
interferon alpha/beta receptor 1
interferon-alpha/beta receptor alpha chain
interferon-beta receptor 1
Type I interferon receptor 1
Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- alpha R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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