IFI16 Antibody

Product Discontinued

IFI16 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 740-795 of Human IFI-16.
• Specificity: IFI-16 (N772) pAb detects endogenous levels of IFI-16 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IFI16
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of IFI-16 (N772) pAb in extracts from HepG2 cells.
• Theoretical MW: 88 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (approx. pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for IFI16 Antibody

• ifi-16
• IFNGIP1gamma-interferon-inducible protein 16
• interferon, gamma-inducible protein 16
• interferon-gamma induced protein IFI 16
• Interferon-inducible myeloid differentiation transcriptional activator
• MGC9466
• PYHIN2

Background

Interferon-gamma inducible protein 16 (IFI16) belongs to the HIN-200 family of transcriptional regulator linked to cell cycle regulation and differentiation by modulating the activities of multiple transcriptional factors, such as p53 and Rb. The HIN-200 (hematopoeitic interferon-inducible nuclear antigens with 200 amino acid repeat) family members contain a DNA binding domain, a transcriptional regulatory domain, DAPIN/PAAD domain associated with interferon response and a binding domain for BRCA1. IFI16 may have a role in the regulation of hematopoeitic cell differentiation and also be involved in DNA repair since it becomes a component of the DNA repair multi-protein BASC complex after UV-induced DNA damage. IFI16 is strongly induced by gamma interferon in vivo.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IFI16