IFI16 Products

Description

IFI16 encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.

Bioinformatics

Entrez	3428 Human
Uniprot	AAH17059 Human AAH17059.1 Human NM_005531 Human Q16666 Human
Product By Gene ID	3428
Alternate Names	Ifi-16 ifi-16 IFNGIP1gamma-interferon-inducible protein 16 interferon, gamma-inducible protein 16 interferon-gamma induced protein IFI 16 Interferon-inducible myeloid differentiation transcriptional activator MGC9466 PYHIN2

Research Areas for IFI16

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Cytokine Research

Related IFI16 Blog Posts

Check out the latest blog posts on IFI16.

STING in Innate Immunity and Cancer: What’s the Buzz About? STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...    Read more.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

Read more IFI16 related blogs.