Human PlGF Quantikine HS ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human PlGF Quantikine HS ELISA Kit Summary

• Background: The Quantikine HS Human PlGF Immunoassay is a 3.5 hour solid phase
  ELISA designed to measure PlGF levels in serum and plasma. It contains
  E. coli-expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained using natural human PlGF showed linear curves ...that were parallel to the standard curves obtained using the Quantikine HS kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
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• Specificity: Natural and recombinant human PlGF.
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PGF

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human PlGF Quantikine HS ELISA Kit

• D12S1900
• PGF
• PGFL
• placenta growth factor
• placental growth factor
• placental growth factor, vascular endothelial growth factor-related protein
• PlGF
• PlGF-2
• PLGFplacental growth factor-like
• SHGC-10760

Background

PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.

Publications for PLGF (HSPG00)(4)

Publications using HSPG00

• AN Burska, PV Giannoudis, BH Tan, D Ilas, E Jones, F Ponchel Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans J Clin Med, 2020-02-11;9(2):. 2020-02-11 [PMID: 32054088] (Human)
• G Merckx, B Hosseinkha, S Kuypers, S Deville, J Irobi, I Nelissen, L Michiels, I Lambrichts, A Bronckaers Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles Cells, 2020-01-28;9(2):. 2020-01-28 [PMID: 32012900] (Human)
• JM Gu, S Yuan, D Sim, K Abe, P Liu, M Rosenbruch, P Bringmann, K Kauser Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease Exp. Hematol., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337222] (Human)
• M Perrotta, A Lori, L Carnevale, S Fardella, G Cifelli, R Iacobucci, F Mastroiaco, D Iodice, F Pallante, M Storto, G Lembo, D Carnevale Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation Cardiovasc. Res., 2018-03-01;114(3):456-467. 2018-03-01 [PMID: 29324984] (Mouse)

Bioinformatics

• Gene Symbol: PGF