Human NRG1-beta 1/HRG1-beta 1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human NRG1-beta 1/HRG1-beta 1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: NRG1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human NRG1-beta 1/HRG1-beta 1 DuoSet ELISA, 15 Plate

• ARIA
• GGF
• GGF2
• HGL
• HRG
• HRG1
• HRGA
• MST131
• MSTP131
• NDF
• neuregulin 1
• Neuregulin1 beta 1
• Neuregulin-1 beta 1
• NRG1-IT2
• SMDF

Background

The neuregulin (also known as heregulin) cytokine family is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. The NRG1 gene is the most pleiotropic, encoding more than 14 soluble or transmembrane proteins. NRG1 isoforms can be classified into type I (neu differentiation factor, NDF; heregulin, HRG; acetylcholine receptor inducing activity, ARIA), type II (glial growth factor, GGF) and type III (sensory and motor neuron-derived factor, SMDF) isoforms. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Publications for Neuregulin-1 beta 1/NRG1 beta 1 (DY377)(20)

Publications using DY377

• Yun, JH;Hong, Y;Hong, MH;Kim, G;Lee, JS;Woo, RS;Lee, J;Yang, EJ;Kim, IS; Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38 Cytokine 2024-02-01 [PMID: 38134557] (Human)
• AK Podder, MA Mohamed, G Tseropoulo, B Nasiri, ST Andreadis Engineering Nanofiber Scaffolds with Biomimetic Cues for Differentiation of Skin-Derived Neural Crest-like Stem Cells to Schwann Cells International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142746] (Human)
• H Yang, W Pan, W Xiao, M Yang, J Xu, J Li, X Zhang Antipsychotic drugs increase Neuregulin1beta1 serum levels in first-episode drug-na�ve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms BMC Psychiatry, 2022-03-25;22(1):217. 2022-03-25 [PMID: 35337293] (Human)
• DH Shin, SH Kim, M Choi, YK Bae, C Han, BK Choi, SS Kim, JY Han Oncogenic KRAS promotes growth of lung cancer cells expressing SLC3A2-NRG1 fusion via ADAM17-mediated shedding of NRG1 Oncogene, 2021-11-06;0(0):. 2021-11-06 [PMID: 34743207] (Human)
• F Mouton-Lig, J Dumurgier, E Cognat, C Hourregue, H Zetterberg, H Vanderstic, E Vanmechele, E Bouaziz-Am, K Blennow, J Hugon, C Paquet CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer's disease Alzheimers Res Ther, 2020-07-20;12(1):88. 2020-07-20 [PMID: 32690068] (Human)
• SJ Wang, R Li, TSC Ng, G Luthria, MJ Oudin, M Prytyskach, RH Kohler, R Weissleder, DA Lauffenbur, MA Miller Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-05-22;6(21):eaaz8521. 2020-05-22 [PMID: 32494745] (Human)
• K Szu?drzy?s, M Jankowski, DP Potaczek, A Undas Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein Dis. Markers, 2020-01-25;2020(0):7190828. 2020-01-25 [PMID: 32076463] (Human)
• S Ryu, JM Lee, CA Bae, CE Moon, KO Cho Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke PLoS ONE, 2019-09-27;14(9):e0222587. 2019-09-27 [PMID: 31560696] (Human, Xenograft)
• C Li, H Tao, X Yang, X Zhang, Y Liu, Y Tang, A Tang Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia Int J Med Sci, 2018-06-04;15(9):900-906. 2018-06-04 [PMID: 30008602] (Human)
• N Schwartz, M Pellach, Y Glick, R Gil, G Levy, D Avrahami, E Barbiro-Mi, Y Nahmias, D Gerber Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array N Biotechnol, 2018-02-10;0(0):. 2018-02-10 [PMID: 29438748] (Human)
• Y Miura, Y Sukawa, S Hironaka, M Mori, K Nishikawa, S Tokunaga, H Okuda, T Sakamoto, K Taku, K Nishikawa, T Moriwaki, Y Negoro, Y Kimura, K Uchino, K Shinozaki, H Shinozaki, N Musha, H Yoshiyama, T Tsuda, Y Miyata, N Sugimoto, T Shirakawa, M Ito, K Yonesaka, K Yoshimura, N Boku, K Nosho, T Takano, I Hyodo Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G) Gastric Cancer, 2017-05-11;0(0):. 2017-05-11 [PMID: 28497176] (Human)
• Heregulin-1� and HER3 in hepatocellular carcinoma: status and regulation by insulin J Exp Clin Cancer Res, 2016-08-11;35(1):126. 2016-08-11 [PMID: 27514687] (Human)
• Patritumab plus trastuzumab and paclitaxel in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer Cancer Sci., 2016-09-15;107(10):1465-1470. 2016-09-15 [PMID: 27452985] (Human)
• Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B, Kong A HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol., 2010-12-21;8(12):e1000563. 2010-12-21 [PMID: 21203579] (Human)
• Hickinson DM, Marshall GB, Beran GJ Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib. Clin Transl Sci, 2009-06-01;2(3):183-92. 2009-06-01 [PMID: 20443891] (Human)
• Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J. Neurosci., 2010-04-14;30(15):5437-50. 2010-04-14 [PMID: 20392965] (Rat)
• Hoffmann I, Bueter W, Zscheppang K, Brinkhaus MJ, Liese A, Riemke S, Dork T, Dammann O, Dammann CE Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns. Brain Behav. Immun., 2009-09-04;24(5):784-91. 2009-09-04 [PMID: 19733651] (Human)
• Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ. Res., 2009-07-30;105(5):500-10. 2009-07-30 [PMID: 19644050] (Human)
• Ky B, Kimmel SE, Safa RN, Putt ME, Sweitzer NK, Fang JC, Sawyer DB, Cappola TP Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation, 2009-07-13;120(4):310-7. 2009-07-13 [PMID: 19597049] (Human)
• Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 2006-07-01;10(1):39-50. 2006-07-01 [PMID: 16843264] (Human)

Review for Neuregulin-1 beta 1/NRG1 beta 1 (DY377) (1)

Average Rating: 5

(Based on 1 review)

reviewed by: Patricia Carulla Martí 06/22/2023

Summary

• Sample Tested: human dermal fibroblast,Supernatant from Human primary fibroblasts (HDFa) cultured in presence or absence of H2O2
• Lot: P1053100

Bioinformatics

• Gene Symbol: NRG1