Human IL-13 R alpha 1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-13 R alpha 1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL13RA1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-13 R alpha 1 DuoSet ELISA, 15 Plate

• bB128O4.2.1 (interleukin 13 receptor, alpha 1)
• Cancer/testis antigen 19
• CD213a1 antigen
• CD213a1
• CT19
• IL-13 R alpha 1
• IL13 receptor alpha-1 chain
• IL-13 receptor subunit alpha-1
• IL13R alpha 1
• IL-13R subunit alpha-1
• IL13R
• IL13RA
• IL-13Ra
• IL13RA1
• IL-13Ra1
• IL-13R-alpha-1
• interleukin 13 receptor, alpha 1
• interleukin-13 receptor subunit alpha-1
• NR4

Background

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Bioinformatics

• Gene Symbol: IL13RA1