Human EPCR DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human EPCR DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PROCR

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human EPCR DuoSet ELISA, 15 Plate

• APC receptor
• CCCA
• CCD41
• CCD41centrosome-associated protein
• CD201 antigen
• CD201
• centrocyclin
• Endothelial cell protein C receptor
• endothelial protein C receptor
• EPCR
• EPCRMGC23024
• PROCR
• protein C receptor, endothelial

Background

EPCR (the Endothelial Protein C Receptor), also known as CD201, is a transmembrane glyoprotein expressed on vascular endothelial cells. EPCR inhibits thrombosis through its interactions with Protein C, activated Protein C (APC), and Coagulation Factors VII, and VIIa. It enhances the activation of Protein C in response to complexes of Thrombin-Thrombomodulin. A soluble form of EPCR inhibits the anti-coagulant activity of APC. EPCR binds to CD11b/CD18 (Mac-1) on monocytes and mediates monocyte adhesion to the vascular endothelium. In addition, it binds to the antigen receptor on gamma/delta T cells, promotes hematopoietic stem cell retention in the bone marrow, and contributes to malaria pathogenicity through binding surface proteins on Plasmodium.

Publications for EPCR (DY2245)(9)

Publications using DY2245

• Bodeau-Livinec, F;Aubouy, A;Besnard, I;Angendu, K;Brisset, J;Royo, J;Kinkpe, E;Ayedadjou, L;Mowendabeka, A;Lathière, T;Boumediène, F;Dossou-Dagba, I;Alao, J;Faucher, JF; Determinants of retinopathy and short-term neurological outcomes after cerebral malaria Scientific reports 2025-04-19 [PMID: 40253461] (Human)
• Keskinidou, C;Vassiliou, AG;Papoutsi, E;Jahaj, E;Dimopoulou, I;Siempos, I;Kotanidou, A; Dysregulated Coagulation and Fibrinolysis Are Present in Patients Admitted to the Emergency Department with Acute Hypoxemic Respiratory Failure: A Prospective Study Biomedicines 2024-05-13 [PMID: 38791043] (Human)
• R Gualtierot, F Tafuri, R Rossio, M Rota, P Bucciarell, B Ferrari, A Giachi, C Suffritti, M Cugno, F Peyvandi, On Behalf Lung Ultrasound Findings and Endothelial Perturbation in a COVID-19 Low-Intensity Care Unit Journal of Clinical Medicine, 2022-09-15;11(18):. 2022-09-15 [PMID: 36143072] (Human)
• MP Ward, FA Saadeh, SA O'Toole, JJ O'Leary, N Gleeson, LA Norris Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway Thrombosis Research, 2021-01-26;200(0):91-98. 2021-01-26 [PMID: 33571724] (Human)
• N Ziliotto, S Meneghetti, E Menegatti, M Baroni, B Lunghi, F Salvi, M Ferracin, A Branchini, D Gemmati, F Mascoli, P Zamboni, F Bernardi, G Marchetti Expression profiles of the internal jugular and saphenous veins: Focus on hemostasis genes Thromb. Res., 2020-05-03;191(0):113-124. 2020-05-03 [PMID: 32438216] (Human)
• H Lécuyer, Z Virion, JP Barnier, S Matczak, S Bourdoulou, E Bianchini, F Saller, D Borgel, X Nassif, M Coureuil An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans PLoS Pathog., 2018-04-09;14(4):e1006981. 2018-04-09 [PMID: 29630665] (Human)
• AG Vassiliou, A Kotanidou, Z Mastora, C Tascini, G Cardinali, SE Orfanos The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients Infect Dis Ther, 2018-03-16;7(0):3-14. 2018-03-16 [PMID: 29549653] (Human)
• Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity. Crit. Care Med., 2012-06-01;40(6):1844-50. 2012-06-01 [PMID: 22610188] (Human)
• Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J. Thromb. Haemost., 2012-02-01;10(2):207-16. 2012-02-01 [PMID: 22151659] (Human)

FAQs for EPCR (DY2245). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: PROCR