HOXD10 Antibody [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

HOXD10 Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human HOXD10
  Arg153-Thr262
  Accession # P28358
• Specificity: Detects human HOXD10 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HOXD10 Antibody [Alexa Fluor® 647]

• homeo box 4D
• homeo box D10
• homeobox D10
• Homeobox protein Hox-4D
• Homeobox protein Hox-4E
• homeobox protein Hox-D10
• HOX4
• Hox-4.4
• HOX4D
• HOX4DHOX4
• HOX4E
• HOXD10

Background

HOXD10 is a sequence-specific transcription factor that belongs to the Abd-B homeobox family.  It is a nuclear protein that is expressed in developing limb buds and is involved in differentiation and limb development.  HOXD10 mutations have been associated with foot deformities such as rocker-bottom foot and the deformity seen in Charcot-Marie-Tooth disease.  HOXD10 also functions as a candidate tumor suppressor.  In gastric cancer there is downregulation in gastric cancer tissues and cell lines relative to normal stomach tissues.  It has also been reported to suppress ovarian cancer, hepatocellular carcinoma and other cancer cells. Re-expression of HOXD10 results in significant inhibition of cell survival, induction of cell apoptosis and impairment of cell migration and invasion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.