HOXA11 Antibody - BSA Free

Western Blot: HOXA11 Antibody [NBP1-80228] - Titration: 0.2-1 ug/ml, Positive Control: Human Uterus.

Immunohistochemistry-Paraffin: HOXA11 Antibody [NBP1-80228] - Human Uterus Tissue, 4-8ug/ml.

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.5 mg/ml

HOXA11 Antibody - BSA Free Summary

• Description: The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
• Immunogen: Synthetic peptide directed towards the C terminal of human HOXA11. Peptide sequence KERRRRPESSSSPESSSGHTEDKAGGSGGQRTRKKRCPYTKYQIRELERE. The peptide sequence for this immunogen was taken from within the described region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HOXA11
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1.0 ug/ml
• Theoretical MW: 34 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 31665361).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, 2% Sucrose
• Preservative: 0.09% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Affinity purified

Alternate Names for HOXA11 Antibody - BSA Free

• homeo box A11
• homeobox A11
• Homeobox protein Hox-1I
• homeobox protein HOXA11
• homeobox protein Hox-A11
• HOX1
• HOX1Ihomeo box 1I

Background

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HOXA11 Antibody (NBP1-80228)(4)

Publications using NBP1-80228

• Fu JF, Wen CJ, Yen TH, Shih LY Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model: Hoxa11 in myeloid sarcoma formation Neoplasia (New York, N.Y.) 2022-04-29 [PMID: 35500545] (WB, Mouse)
• JF Fu, LY Shih, TH Yen HOXA11 plays critical roles in disease progression and response to cytarabine in AML Oncology reports, 2021-06-03;46(1):. 2021-06-03 [PMID: 34080665] (Western Blot, Mouse)
• Grasso A, Navarro R, Balaguer N et al. Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium J. Clin. Endocrinol. Metab. 2019-10-29 [PMID: 31665361] (Human)
• Tal R, Shaikh S, Pallavi P et al. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy PLoS Biol. 2019-09-01 [PMID: 31513564] (WB, Mouse)

Review for HOXA11 Antibody (NBP1-80228) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Ashwini Katre IHC-P Human 03/05/2014

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Human pap serous carcinoma
• Species: Human
• Lot: QC6280

Bioinformatics

• Gene Symbol: HOXA11
• Uniprot:
  • NP_034580(Mouse)