HOMER1 Antibody (666241) [Alexa Fluor® 700]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 666241
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

HOMER1 Antibody (666241) [Alexa Fluor® 700] Summary

• Immunogen: Synthetic peptide KFGQWADSRA corresponding to aa 73-82 of human HOMER1
  Accession # Q86YM7
• Specificity: Detects human HOMER1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HOMER1 Antibody (666241) [Alexa Fluor® 700]

• homer homolog 1 (Drosophila)
• HOMER
• HOMER1
• homer-1
• HOMER1A
• HOMER1B
• HOMER-1B
• HOMER1C
• SYN47
• SYN47neuronal immediate early gene, 1
• Ves-1

Background

HOMER1 is an approximately 48 kDa cytoplasmic protein that regulates the cell surface localization of neuronal mGluR1 and mGluR5 metabotropic glutamate receptors. It also functions in striated muscle mechanotransduction and excitation-contraction coupling by regulating the localization of transient receptor potential (TRP) channels and the coupling of ryanodine receptors to Cav1.2 calcium channels. Alternately spliced isoforms of human HOMER1 lack either the C-terminal half of the molecule (aa 178-354) or 130 aa following the WH1 domain (aa 99-228). Particular isoforms show distinct effects on hippocampal neuronal plasticity and the maintenance of extracellular glutamate levels in the prefrontal cortex. Within aa 73-82, human HOMER1 shares 100% aa sequence identity with mouse and rat HOMER1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.