Synthetic peptide derived from N terminal region of Human Histone H3, containing Citrulline at position 2;8;17
Citrulline 17, Citrulline 8, Citrulline 2
The rabbit polyclonal reacts specifically with human Histone H3 Citrulline at either position 2 and or 8 and or 17. Not yet tested in other species, but the should react with a wide range of species due to sequence homology.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Methylation of arginine residues within histone H3 has been linked to active transcription. However, the mechanism of demethylation of histones has remained elusive. Recently a process termed deimination has been described that converts histone arginine to citrulline and antagonizes arginine methylation (Cuthbert et al., 2004).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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