HIST1H2AC Antibody [Janelia Fluor® 646]

Product Discontinued

HIST1H2AC Antibody [Janelia Fluor® 646] Summary

• Immunogen: histone cluster 1, H2ac. (Uniprot# Q93077)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HIST1H2AC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for HIST1H2AC Antibody [Janelia Fluor® 646]

• dJ221C16.4
• H2A/l
• H2AFLmember L
• histone 1, H2ac
• histone cluster 1, H2ac
• histone H2A type 1-C
• Histone H2A/l
• histone H2AC
• MGC99519

Background

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The HIST1H2AC gene is found in the large histone gene cluster on chromosome 6 and codes for a histone H2A type 1-c protein that is 130 amino acids long and 14 kDA. This protein lacks polyA tails but obtains palindromic termination elements. H1 proteins are essential in forming chromatin fiber and for the condensation of nucleosome chains into higher-order structured fibers. HIST1H2AC is involved in histone modification, telomere maintenance, nucleosome assembly, and signal transduction activin A signaling regulation. It interacts with other genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H4E. Researchers have investigated its role in various diseases such as x inactivation, immunodeficiency, lupus, hemochromatosis, and riddle syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HIST1H2AC