HIST1H2AC Products

Description

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The HIST1H2AC gene is found in the large histone gene cluster on chromosome 6 and codes for a histone H2A type 1-c protein that is 130 amino acids long and 14 kDA. This protein lacks polyA tails but obtains palindromic termination elements. H1 proteins are essential in forming chromatin fiber and for the condensation of nucleosome chains into higher-order structured fibers. HIST1H2AC is involved in histone modification, telomere maintenance, nucleosome assembly, and signal transduction activin A signaling regulation. It interacts with other genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H4E. Researchers have investigated its role in various diseases such as x inactivation, immunodeficiency, lupus, hemochromatosis, and riddle syndrome.

Bioinformatics

Entrez	319164 Mouse 499676 Rat 8334 Human
Uniprot	NM_003512 Human NP_003503 Human NP_003503.1 Human Q93077 Human
Product By Gene ID	8334
Alternate Names	dJ221C16.4 H2A/l H2AFLmember L histone 1, H2ac histone cluster 1, H2ac histone H2A type 1-C Histone H2A/l histone H2AC MGC99519

Research Areas for HIST1H2AC

Find related products by research area and learn more about each of the different research areas below.

Cancer