HDAC3 Antibody (C.15100145)

Product Discontinued

HDAC3 Antibody (C.15100145) Summary

• Description: Monoclonal antibody raised in mouse against human HDAC3 (Histone deacetylase 3), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein.
• Immunogen: The exact immunogen is propietary information.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: HDAC3
• Purity: Concentrated Supernatant

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation 5 uL

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Culture Medium
• Preservative: 0.05% Sodium Azide
• Purity: Concentrated Supernatant

Alternate Names for HDAC3 Antibody (C.15100145)

• EC 3.5.1.98
• HD3RPD3-2RPD3
• HDAC3
• Histone Deacetylase 3
• KDAC3
• RPD3-2
• SMAP45

Background

HDAC3 (UniProt/Swiss-Prot entry O15379) catalyzes the deacetylation of lysine residues in the N-terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is associated with gene repression. Histone deacetylation is established by the formation of large multiprotein complexes. HDAC3 may bind to the zinc-finger transcription factor YY1, thereby regulating transcription. It is also able to modulate cell growth and apoptosis through the interaction with p53 and is thought to be essential for the repression of the POU1F1 transcription factor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HDAC3