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Granzyme A Antibody (GA6)

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Summary
Product Discontinued
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    • Catalog Number
      NB600-719
    • Availability
      Product Discontinued

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Granzyme A Antibody (GA6) Summary

Immunogen
Recombinant Granzyme A (Human).
Localization
Secreted, Cytoplasmic granules.
Specificity
Granzyme A (GA6)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
GZMA
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:100-1:2000
Application Notes
IHC-P: Perform heat mediated antigen retrieval before commencing with IHC staining protocol.WB: Use at an assay dependent dilution. Predicted molecular weight: 31.4 kDa(recognises a 60kD disulphide-linked homodimeric protein). Optimal dilutions/concentrations should be determined by the end user.
Control
Granzyme M Overexpression Lysate

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate Buffered Saline
Preservative
0.9% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Granzyme A Antibody (GA6)

  • CTL Tryptase
  • CTLA3
  • CTLA3Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factorserine protease)
  • Cytotoxic T-lymphocyte proteinase 1
  • EC 3.4.21
  • Fragmentin-1
  • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
  • Granzyme A
  • Granzyme-1
  • GZMA
  • H factor
  • Hanukkah factor
  • HF
  • HFSP
  • HFSPEC 3.4.21.78

Background

The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Control Lysate(s)

Granzyme M Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GZMA
Entrez
Uniprot