GPR15 Antibody

Immunohistochemistry-Paraffin: GPR15 Antibody [NBP1-02651] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Product Discontinued

GPR15 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from C-terminal cytoplasmic domain of human GPR15.
• Specificity: Human GPR15. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Monkey (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GPR15
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Gibbon (100%), Marmoset (89%), Mouse (89%), Bat (89%), Bovine (89%), Elephant (89%), Panda (89%), Rabbit (89%), Canine (84%), Hamster (84%), Equine (84%), Porcine (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GPR15 Antibody

• Bob
• Brother of Bonzo
• G protein-coupled receptor 15
• GPR15
• G-protein coupled receptor 15
• MGC126828
• MGC126830

Background

G protein-coupled receptor GPR15 is an Orphan-A GPCR with an unknown ligand. Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use BOB/GPR15 for productive infection, suggesting that this cofactor may play a role in HIV-1 pathogenesis and transmission.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GPR15 Antibody (NBP1-02651)(1)

Publication using NBP1-02651

• Okamoto Y, Shikano S. Differential phosphorylation signals control endocytosis of GPR15. Mol. Biol. Cell. 2017-06-14 [PMID: 28615320]

Bioinformatics

• Gene Symbol: GPR15
• Entrez:
  • 2838(Human)
• Uniprot:
  • P49685()