GKAP/DLGAP1 Antibody (727425) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clone: 727425
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

GKAP/DLGAP1 Antibody (727425) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human GKAP
  Lys368-Glu472
  Accession # O14490
• Specificity: Detects human GKAP in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GKAP/DLGAP1 Antibody (727425) [Alexa Fluor® 647]

• DAP1
• DAP-1-ALPHA
• DAP-1DAP-1-BETA
• discs, large (Drosophila) homolog-associated protein 1
• disks large-associated protein 1
• DLGAP1
• GKAP
• GKAPMGC88156
• hGKAP
• PSD-95/SAP90 binding protein 1
• PSD-95/SAP90-binding protein 1
• SAP90/PSD-95-associated protein 1
• SAPAP1
• SAPAP1Guanylate kinase-associated protein

Background

GKAP, also known as DAP1, DLGAP, and SAPAP1, is an approximately 45 kDa cytoplasmic membrane associated protein. GKAP is a component of a neuronal postsynaptic complex that also includes PSD-95 and SHANK. This complex links neurotransmitter channels with the cytoskeleton and can promote NMDA R channel opening. Alternate splice forms of human GKAP have N-terminal and/or C-terminal truncations and are differentially expressed during brain development. Within aa 368-472 human, mouse, and rat GKAP share 100% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.