GCHFR Antibody (846011) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 846011
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

GCHFR Antibody (846011) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human GCHFR in ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GCHFR Antibody (846011) [Alexa Fluor™ Plus 594]

• GCHFR
• GFRP
• GFRPP35
• GTP cyclohydrolase I feedback regulator
• GTP cyclohydrolase I feedback regulatory proteinGTP cyclohydrolase 1 feedback regulatory protein
• HsT16933
• MGC138467
• MGC138469
• p35

Background

GCHFR (GTP cyclohydrolase I feedback receptor), also called GFRP, is an 84 amino acid enzyme inhibitor that binds to and regulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I is the rate-limiting enzyme in biosynthesis of tetrahydrobiopterin, an essential cofactor for nitric oxide synthases and aromatic hydrolases. GCHFR is found as a 20 kDa homodimer in the nucleus and cytoplasm of multiple cell types, including endothelial cells, keratinocytes and melanocytes. Human GCHFR shares 93% amino acid sequence identity with mouse and rat GCHFR, which in turn share 100% identity with each other.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.