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gamma-Synuclein Antibody

Images

 
Western Blot: gamma-Synuclein Antibody [NBP1-89996] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells.
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
Immunohistochemistry: gamma-Synuclein Antibody [NBP1-89996] - Staining of human adrenal gland shows high expression.
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Staining of human colon shows low expression as expected.
Orthogonal Strategies: Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Analysis in human adrenal gland and liver tissues using NBP1-89996 antibody. Corresponding SNCG RNA-seq data are ...read more
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody [NBP1-89996] - Staining of human liver shows no positivity in hepatocytes as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

gamma-Synuclein Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: GAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SNCG
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
gamma-Synuclein Recombinant Protein Antigen (NBP1-89996PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (81%), Rat (82%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for gamma-Synuclein Antibody

  • BCSG1
  • BCSG1PERSYN
  • Breast cancer-specific gene 1 protein
  • gamma-Synuclein
  • persyn
  • PRSN
  • SNCG
  • SRPRSN
  • Synoretin
  • synuclein, gamma (breast cancer-specific protein 1)
  • Synuclein-gamma

Background

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. May be a centrosome-associated protein. Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SNCG