Galectin-3 Antibody (5C21) [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF
Clone
5C21
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Galectin-3 Antibody (5C21) [DyLight 405] Summary

Immunogen
Full length recombinant human Galectin-3 expressed in and purified from E. coli. [UniProt# P17931]
Localization
Cytoplasm. Nucleus. Secreted. Note: Secreted by a non-classical secretory pathway and associates with the cell surface.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LGALS3
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This Galectin-3 (5C21) antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at approximately 30 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Galectin-3 Antibody (5C21) [DyLight 405]

  • AGE-R3
  • Carbohydrate-binding protein 35
  • CBP 35,35 kDa lectin
  • CBP35
  • GAL3
  • Gal-3
  • galactin-3
  • Galactose-specific lectin 3
  • Galactoside-binding protein
  • GALBPCBP35
  • Galectin3
  • Galectin-3
  • GALIG
  • IgE-binding protein
  • L29
  • L31
  • L-31
  • Laminin-binding protein
  • Lectin L-29
  • lectin, galactoside-binding, soluble, 3
  • LGALS2
  • LGALS3
  • Mac-2 antigen
  • Mac-2
  • MAC2GAL3

Background

Galectin-3 (LGALS3 or Mac-2 antigen), is a 26 kD beta-galactoside-binding protein from galectin family and it is ubiquitously expressed with localization dependent on cell type as well as proliferative status. Galectin-3 is expressed in many immunocompetent and inflammatory cells, including macrophages, dendritic cells, eosinophils, mast cells, uterine NK cells and activated T and B cells, and it is localized in nucleus, cytoplasm or on cell surface as well as in extracellular compartments. Extracellularly, galectin-3 acts as an adhesion molecule whereas intracellular galectin-3 implicates in processes that are pivotal for basic cellular functions, such as pre-mRNA splicing regulation of cell growth, cell cycle progression and apoptosis. Galectin-3 binds and interacts with numerous ligands in intra-/extracellular environment such as DMBT1, ITGA3, ITGB1, CSPG4, LGALS3BP, LYPD3, CYHR1, UACA etc. for modulating cellular signals responsible fpr its biological functions such as phagocytosis, cell growth/proliferation, adhesion and apoptosis in normal as well as cancer cells. Circulating galectin-3 concentrations increases more than 30-fold in bloodstream of patients with various cancers and patients with metastatic disease have higher concentrations of circulating galectin-3 than those with only localized tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol LGALS3
Entrez