GABA-B R2 [p Ser783] Antibody

Images

 
Western Blot: GABA-B R2 [p Ser783] Antibody [NB100-61101] - Rat synaptic membrane showing specific immunolabeling of the ~102 k GABAB R2 protein phosphorylated at Ser783 (control). The phosphospecificity of this ...read more

Product Details

Summary
Reactivity Mu, Rt, Hu, Mu, Bv, Ch, Pm, XpSpecies Glossary
Applications WB, ICC/IF, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GABA-B R2 [p Ser783] Antibody Summary

Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer783 of GABAB R2.
Modification
p Ser783
Specificity
Specific for apparox. 102k GABAB R2 phosphorylated at Ser783. Immunolabeling of the GABA783B R2 band is completely blocked by gamma-phosphatase treatment.
Predicted Species
Human (100%), Mouse (100%), Bovine (100%), Chicken (100%), Primate (100%), Xenopus (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GABBR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:500
  • Immunofluorescence 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for GABA-B R2 [p Ser783] Antibody

  • G protein-coupled receptor 51
  • GABA B R2
  • GABABR2
  • GABA-BR2
  • GABA-B-R2
  • GABABR2GABA-B receptor 2
  • GABBR2
  • gamma-aminobutyric acid (GABA) B receptor, 2
  • gamma-aminobutyric acid type B receptor subunit 2
  • gb2
  • GPR51
  • GPR51GABA-B receptor, R2 subunit
  • GPRC3B
  • GPRC3BFLJ36928
  • G-protein coupled receptor 51
  • HG20HRIHFB2099

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for GABA-B R2 Antibody (NB100-61101). (Showing 1 - 1 of 1 FAQ).

  1. Are there neutralizing peptides for this antibody?
    • There is no neutralizing peptide available for this antibody.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GABBR2
Entrez
Uniprot