GABA-AR alpha 3 Antibody

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Immunohistochemistry-Paraffin: GABA A R alpha 3 Antibody [NBP1-52391] - Analysis of anti-GABRA3 antibody with human brain, cortex at concentration 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bt, Bv, Eq, Ha, Mk, Pm, Rb, Ca, Ch, OpSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

GABA-AR alpha 3 Antibody Summary

Immunogen
Synthetic peptide NRESAIKGMIRKQ from C-Terminus of human GABRA3 (NP_000799.1).
Specificity
Human GABRA3.
Predicted Species
Opossum (100%), Chicken (92%), Canine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GABRA3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2.5 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Platypus (100%), Panda (92%), Turkey (85%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GABA-AR alpha 3 Antibody

  • GABA A R alpha 3
  • GABA(A) receptor subunit alpha-3
  • GABAARa3
  • GABRA3
  • gamma-aminobutyric acid (GABA) A receptor, alpha 3
  • gamma-aminobutyric acid receptor subunit alpha-3
  • gamma-animobutyric acid (GABA) A receptor, alpha 3
  • MGC33793

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GABRA3
Entrez
Uniprot