GAB3 Antibody (720306) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 720306
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

GAB3 Antibody (720306) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human GAB-3 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GAB3 Antibody (720306) [Alexa Fluor™ Plus 555]

• DOS/Gab family member 3
• Gab3 scaffolding protein
• GAB3
• GRB2-associated binder 3
• GRB2-associated binding protein 3
• GRB2-associated-binding protein 3
• Growth factor receptor bound protein 2-associated protein 3

Background

GAB3 (GRB2-associated-binding protein 3) is a ~75-80 kDa member of the Gab family of scaffolding proteins which show overlapping expression in hematopoietic cells. All contain an N-terminal pleckstrin homology domain and multiple tyrosine phosphorylation and SH2 and SH3 domain binding sites.  M-CSF stimulation of myeloid precursors  through M-CSF R co-induces GAB3 and the associated adaptor protein GRAP2, and causes macrophage differentiation associated with tyrosine phosphorylation of GAB3. Over amino acids (aa) 121-263, human GAB3 shares 73% aa identity with mouse GAB3.  A potential isoform of 548 aa lacks aa 509-548, while another of 488 aa lacks aa 173-356 and diverges at aa 475. A third potential isoform of 206 aa has an alternate start site at aa 380.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.