Frizzled-4 Antibody

Immunohistochemistry-Paraffin: Frizzled-4 Antibody [NLS4911] - Anti-FZD4 / Frizzled 4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Frizzled-4 Antibody [NLS4911] - Skeletal Muscle

Immunohistochemistry-Paraffin: Frizzled-4 Antibody [NLS4911] - Analysis of anti-FZD4 / Frizzled 4 antibody with human kidney.

Immunohistochemistry-Paraffin: Frizzled-4 Antibody [NLS4911] - Anti-FZD4 / Frizzled 4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

Frizzled-4 Antibody Summary

• Immunogen: Synthetic 13 amino acid peptide from C-terminus of human FZD4 / Frizzled 4.
• Localization: Cell Membrane
• Specificity: Human FZD4 / Frizzled 4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Xenopus (92%), Turkey (100%), Opossum (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FZD4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 25 ug/ml

Reactivity Notes

Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%), Lizard (92%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Frizzled-4 Antibody

• CD344 antigen
• CD344
• EVR1
• exudative vitreoretinopathy 1
• FEVR
• frizzled (Drosophila) homolog 4
• frizzled homolog 4 (Drosophila)
• Frizzled4
• Frizzled-4
• Fz-4
• FZD4
• FZD4S
• FzE4
• GPCR
• hFz4
• MGC34390
• WNT receptor frizzled-4

Background

FZD4 is a Frizzled Receptor involved in mediating Wnt signaling. A splicing variant of frizzled-4, FZD4s, encodes a soluble-type positive regulator of the Wnt signaling pathway. Mutations in FZD4 are associated with retinal angiogenesis. FZD4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain. FZD4 expression has not been reported in several cancer cell lines studied. ESTs have been isolated from adipose, adrenal, B-cell/lung/testis, bone marrow, brain, breast, colon, embryo, gallbladder, head/neck, heart, heart/melanocyte/uterus, kidney, liver, liver/spleen, lung, placenta, prostate, skeletal muscle, skin, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FZD4
• Entrez:
  • 8322(Human)