FLNC Antibody


Western Blot: FLNC Antibody [NBP2-79816] - Total protein from HeLa was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 1.0 ug/ml ...read more
Immunocytochemistry/ Immunofluorescence: FLNC Antibody [NBP2-79816] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.5% Triton-X100. The cells were ...read more
Immunohistochemistry-Paraffin: FLNC Antibody [NBP2-79816] - IHC analysis of a formalin fixed paraffin embedded (FFPE) tissue section of human skeletal muscle using FLNC antibody (NBP2-79816) at 1:200 dilution. The ...read more
Flow Cytometry: FLNC Antibody [NBP2-79816] - An intracellular stain was performed on NIH3T3 cells with NBP2-79816 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with ...read more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
1.0 mg/ml

Order Details

FLNC Antibody Summary

Recombinant protein made to an internal portion of the human FLNC protein (amino acids 270-468) [UniProt Q14315]
Immunogen affinity purified
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  • Western Blot 1 ug/ml
  • Flow Cytometry 1 ug/million cells/ml
  • Immunocytochemistry/Immunofluorescence 2 ug/ml
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200

Packaging, Storage & Formulations

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
0.02% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for FLNC Antibody

  • ABP-280
  • ABP280A
  • ABP-280-like protein
  • ABPA
  • ABP-L
  • ABPLABP-L, gamma filamin
  • Actin-binding-like protein
  • filamin 2
  • filamin C, gamma (actin binding protein 280)
  • filamin C, gamma
  • filamin-2
  • filamin-C
  • FLJ10186
  • FLN2actin binding protein 280
  • FLNc
  • FLN-C
  • Gamma-filamin


FLNC, Filamin-c, Filamin-2 (FLN2), Actin binding-like protein (APBL) (290.8 kDa) is an isoform of the Filamin proteins family. Filamins are broadly expressed and function as actin-binding and actin-crosslinking proteins. Structurally, Filamins consist of three main domains; N-terminal actin-binding domain, multiple central immunoglobulin (Ig) domains, and a C-terminal domain which supports homodimerization (1, 2). Functionally, Filamins play a role in cytoskeleton structure through interactions with actin, but they are implicated in a wide range of processes through their interactions with diverse molecular partners such as signaling molecules (MKK4, JNK1), ion channels (Kv4.2, Kir2.1), receptors (Insulin, Calcitonin), and transcription factors (Smad1-6, Foxc1) (3).

Three isoforms of Filamin are expressed in mammals, identified as FLNA, FLNB and FLNC. FLNC is considered a muscle specific Filamin isoform for its high expression in cardiac and skeletal muscles. In muscle tissue, FLNC localizes to the Z-line, sarcolemma, myotendinous and intercalated disks (2). FLNC interacts with various muscle proteins via a non-conserved sequence within its Ig domain 20. Some muscle binding partners for FLNC include gamma and delta-sarcoglycans in the sarcolemma, and FATZ, myozenins, myotilin and myopodin in the Z-discs (2, 4). FLNC variants are associated with various inherited pathological conditions including myofibrillar myopathy 5, distal myopathy 4, dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy (2, 5).


1. Chiang, W., Greaser, M. L., & Lyons, G. E. (2000). Filamin isogene expression during mouse myogenesis. Developmental Dynamics. https://doi.org/10.1002/(sici)1097-0177(200001)217:1<99::aid-dvdy9>3.3.co;2-x

2. Leber, Y., Ruparelia, A. A., Kirfel, G., van der Ven, P. F. M., Hoffmann, B., Merkel, R.,... Furst, D. O. (2016). Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddw135

3. Nakamura, F., Stossel, T. P., & Hartwig, J. H. (2011). The filamins: Organizers of cell structure and function. Cell Adhesion and Migration. https://doi.org/10.4161/cam.5.2.14401

4. Thompson, T. G., Chan, Y. M., Hack, A. A., Brosius, M., Rajala, M., Lidov, H. G. W.,... Kunkel, L. M. (2000). Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein. Journal of Cell Biology. https://doi.org/10.1083/jcb.148.1.115

5. Brodehl, A., Ferrier, R. A., Hamilton, S. J., Greenway, S. C., Brundler, M. A., Yu, W.,... Scherer, S. (2016). Mutations in FLNC are Associated with Familial Restrictive Cardiomyopathy. Human Mutation. https://doi.org/10.1002/humu.22942


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-79816AF350
Alexa Fluor 405 NBP2-79816AF405
Alexa Fluor 488 NBP2-79816AF488
Alexa Fluor 532 NBP2-79816AF532
Alexa Fluor 594 NBP2-79816AF594
Alexa Fluor 647 NBP2-79816AF647
Alexa Fluor 700 NBP2-79816AF700
Alexa Fluor 750 NBP2-79816AF750
Allophycocyanin NBP2-79816APC
Biotin NBP2-79816B
DyLight 350 NBP2-79816UV
DyLight 405 NBP2-79816V
DyLight 488 NBP2-79816G
DyLight 550 NBP2-79816R
DyLight 594 NBP2-79816DL594
DyLight 650 NBP2-79816C
DyLight 680 NBP2-79816FR
DyLight 755 NBP2-79816IR
FITC NBP2-79816F
HRP NBP2-79816H
Janelia Fluor 549 NBP2-79816JF549
Janelia Fluor 646 NBP2-79816JF646
PE NBP2-79816PE
PerCP NBP2-79816PCP

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Gene Symbol FLNC