FKBP13/FKBP2 Antibody [Alexa Fluor® 700]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 700

FKBP13/FKBP2 Antibody [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human FKBP13
  Ala22-Leu142
  Accession # P26885
• Specificity: Detects endogenous human, mouse, and rat FKBP13 in Western blots. In Western blots, this antibody does not cross‑react with recombinant human FKBP12, FKBP25, FKBP38, FKBP51 or FKBP52.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP13/FKBP2 Antibody [Alexa Fluor® 700]

• EC 5.2.1.8,13 kDa FK506-binding protein
• FK506 binding protein 2, 13kDa
• FK506-binding protein 2 (13kD)
• FK506-binding protein 2
• FKBP13
• FKBP13,13 kDa FKBP
• FKBP-13proline isomerase
• FKBP2
• FKBP-2
• Immunophilin FKBP13
• peptidyl-prolyl cis-trans isomerase FKBP2
• PPIase FKBP2
• PPIase
• rapamycin-binding protein
• rotamase

Background

FK506 binding protein, 13 kilodalton molecular weight (FKBP13), also called FKBP2, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans‑proline residues critical for proper folding of proteins. The immunosuppressants FK506 and rapamycin are potent inhibitors of FKBP13. This isomerase is localized in the endoplasmic reticulum and is also associated with cytoskeletal elements such as erythrocyte band 4.1. FKBP13 levels are increased by treatments that affect golgi protein processing such as tunicamycin and heat shock, suggesting that FKBP13 is important in the unfolded protein response observed with endoplasmic reticulum stress.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.