FERMT3/URP2 Antibody

Western Blot: FERMT3/URP2 Antibody [NBP1-51974] - Analysis of URP2 in Human Peripheral Blood Mononucleocytes lysate (35ug protein in RIPA buffer) using NBP1-51974 at 1ug/ml. Primary incubation was 1 hour. Detected bychemiluminescence.

• Reactivity: Hu, Mu, Rt, Ca
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

FERMT3/URP2 Antibody Summary

• Description: Novus Biologicals Goat FERMT3/URP2 Antibody (NBP1-51974) is a polyclonal antibody validated for use in WB and ELISA. Anti-FERMT3/URP2 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-ERARGEELDED corresponding to C-Terminus according to NP_848537.1.
• Epitope: C-ERARGEELDED
• Specificity: This antibody is expected to recognize both isoforms (NP_113659.3, NP_848537.1).
• Predicted Species: Mouse (100%), Rat (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FERMT3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:2000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 75 kDa band observed in human peripheral blood mononucleocytes lysates (calculated MW of 75.4 kDa band according to NP_113659.3).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FERMT3/URP2 Antibody

• fermitin family member 3
• FERMT3
• KIND3
• KIND3fermitin family homolog 3 (Drosophila)
• Kindlin 3
• Kindlin-3
• MGC10966
• MIG-2
• MIG2B
• MIG2BURP2SF
• MIG2-like protein
• UNC-112 related protein 2
• UNC112C
• Unc-112-related protein 2
• URP2
• URP2fermitin family homolog 3
• URP2SF

Background

URP2 plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3(ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelialcells. Required for activation of integri

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FERMT3/URP2 Antibody (NBP1-51974)(1)

Publication using NBP1-51974

• Svensson L, Howarth K, McDowall A et al. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med 2009-03-01 [PMID: 19234463]

Bioinformatics

• Gene Symbol: FERMT3
• Entrez:
  • 83706(Human)
  • 108101(Mouse)
  • 309186(Rat)
• Uniprot:
  • NP_113659.3(Human)