FEM1B Antibody

Product Discontinued

FEM1B Antibody Summary

• Immunogen: Rabbit anti-F1Aalpha polyclonal antibody was raised against a peptide (DINYQDQIPRTLEE) corresponding to amino acids 609 to 622 of human F1Aalpha (1). This sequence is identical to the corresponding sequence of mouse FEM1beta (2).
• Specificity: F1Aa
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FEM1B
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-1 ug/ml
• Application Notes: This polyclonal antibody can be used for detection of F1Aa by Western blot at 0.5 - 1 ug/ml. Mouse liver tissue lysate can be used as positive control and an approximately 70 kDa band can be detected. It is human, mouse, and rat reactive.

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: IgG purified

Alternate Names for FEM1B Antibody

• DKFZp451E0710
• F1AA
• F1A-alpha
• FEM-1 (C.elegans) homolog b
• fem-1 homolog b (C. elegans)
• FEM1b
• FEM1-beta
• FEM-1-like death receptor binding protein
• Fem-1-like death receptor-binding protein alpha
• Fem-1-like in apoptotic pathway protein alpha
• FIAA
• KIAA0396
• protein fem-1 homolog B

Background

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1beta (1,2). F1Aalpha/FEM1beta is the homologue of C. elegans sex determining protein FEM-1 (1,2). FEM-1/F1Aalpha is cleaved by CED-3 and caspase (3). FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues (1,2)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FEM1B
• Entrez:
  • 10116(Human)
  • 60327(Rat)