FEM1B Products

Description

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aa and FEM1b (1,2). F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aa is cleaved by CED-3 and caspase (3). FEM-1/F1Aa associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues.

Bioinformatics

Entrez	10116 Human 60327 Rat
Uniprot	AAF05314 Human NM_015322 Human NP_056137 Human NP_056137.1 Human Q9UK73 Human
Product By Gene ID	10116
Alternate Names	DKFZp451E0710 F1AA F1A-ALPHA F1A-alpha FEM-1 (C.elegans) homolog b fem-1 homolog b (C. elegans) FEM1b FEM1-beta FEM-1-like death receptor binding protein Fem-1-like death receptor-binding protein alpha Fem-1-like in apoptotic pathway protein alpha FIAA KIAA0396 protein fem-1 homolog B

Research Areas for FEM1B

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology