Exosome component 10 Antibody (1E6) - Azide and BSA Free

ELISA: Exosome component 10 Antibody (1E6) [H00005394-M08] - Exosome component 10 Antibody (1E6) [H00005394-M08] - Detection limit for recombinant GST tagged EXOSC10 is approximately 1ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 1E6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Exosome component 10 Antibody (1E6) - Azide and BSA Free Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: EXOSC10 (NP_001001998.1, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKD
• Specificity: EXOSC10 - exosome component 10 (1E6)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: EXOSC10
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Exosome component 10 Antibody (1E6) - Azide and BSA Free

• autoantigen PM-SCL
• EC 3.1.13.-
• exosome component 10
• P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
• p2
• p3
• p4
• PM/Scl-100Autoantigen PM/Scl 2
• PM-Scl
• PMSCL2PMSCL
• polymyositis/scleroderma autoantigen 2 (100kD)
• Polymyositis/scleroderma autoantigen 2
• polymyositis/scleroderma autoantigen 2, 100kDa
• RRP6
• Rrp6p
• RRP6Polymyositis/scleroderma autoantigen 100 kDa

Background

Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease . Plays a role in replication-dependent histone mRNA degradation. Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Exosome component 10 Antibody (H00005394-M08)(1)

Publication using H00005394-M08

• Brooks SA. Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system. Wiley Interdiscip Rev RNA 2010-09-01 [PMID: 21935888]

Bioinformatics

• Gene Symbol: EXOSC10
• Entrez:
  • 5394(Human)
• Uniprot:
  • NP_001001998(Human)